Father of Oncology discovers Iron-Related Genes involved in Blood Cancers. Blood cancer (hematologic cancer) is cancer that begins in blood-forming tissue, such as the bone marrow, or in the cells of the immune system. Examples of blood cancer are leukemia, lymphoma, and multiple myeloma. Although the specific cause of blood cancer is not known, a number of factors are associated with its development, researchers say. Melbourne researchers have developed a new genome editing technology that can target and kill blood cancer cells with high accuracy. CRISPR is a unique approach that could potentially be used for treating any disease that is caused by genetic mutations. How are genes involved in blood cancers? Researchers say that cancer is often the result of multiple DNA mutations that accumulate in cells over a lifetime; all cancers begin when one or more genes in a cell are mutated. The Father of Oncology says that blood cancer is a form of iron lottery. Iron is an essential element for both normal and cancerous cells. The body absorbs 10% of the iron encountered in dietary sources each day, but has no efficient means of rapidly eliminating excess iron, other than loss of blood. Theoretically, iron, in excess of what is needed to satisfy metabolic demand, is stored bound to the iron storage protein ferritin. Both ferritin and transferrin are used as blood markers to monitor iron load. Iron balance is regulated by the peptide hormone hepcidin. In fact, iron deficiency or iron overload is a question of a few milligrams/grams of iron. Local/regional iron overload results from inherited defects in genes involved in iron absorption, transport, or regulation. Non-genetic local/regional iron overload can result from a variety of conditions (infections, chronic diseases, radiation, chemical carcinogens, excessive dietary intake of iron, long-term hemodialysis, old age, etc). At the cellular level, blood cancer occurs when cellular iron overload chaotically affects cellular molecules and organelles (DNA, chromosomes, mitochondria, etc). Blood cancer occurs when excessive iron is deposited in the bone marrow or in the lymphatic system. Blood cancer is always caused by iron-related genes (genes directly/indirectly involved in iron metabolism) and iron-related events (when excessive iron accumulates within blood-forming tissue due to various carcinogenic events). The spectrum of known disorders of iron metabolism has expanded dramatically over the past years. It is clear that researchers have not yet identified all genes involved in iron metabolism. Although the genetic defects leading to sideroblastic anemia (SA) are heterogeneous, they all affect the efficiency of heme production within erythroblast mitochondria, leading to iron-overloaded mitochondria that form a characteristic ring around the cell nucleus. Abnormal, iron-saturated red cells are present in the blood of people who have this disease. SA may lead to leukemia. Removal of blood initiates the compensatory synthesis of new red blood cells in bone marrow. Anyone can get a blood cancer at any age, but clinical iron-deficiency methods can successfully neutralize blood cancer. http://www.medicalnewstoday.com/opinions/183856 ; http://www.medicalnewstoday.com/opinions/183762 ; http://www.medicalnewstoday.com/opinions/183624 ; http://www.medicalnewstoday.com/opinions/183512 ; http://www.medicalnewstoday.com/opinions/183446 ; http://www.medicalnewstoday.com/opinions/183420 ; http://www.medicalnewstoday.com/opinions/183391 ; http://www.medicalnewstoday.com/opinions/183292 ; http://www.medicalnewstoday.com/opinions/183218 ; http://www.medicalnewstoday.com/opinions/183149 ; http://www.medicalnewstoday.com/opinions/183138 ; http://www.medicalnewstoday.com/opinions/183071 ; http://www.medicalnewstoday.com/opinions/183019 ; http://www.medicalnewstoday.com/opinions/182995 ; http://www.medicalnewstoday.com/opinions/182986 ; http://www.medicalnewstoday.com/opinions/182896 ; http://www.medicalnewstoday.com/opinions/182837 ; http://www.medicalnewstoday.com/opinions/182805 ; http://www.medicalnewstoday.com/opinions/182753 ; http://www.medicalnewstoday.com/opinions/182701 ; http://www.medicalnewstoday.com/opinions/182679 ; http://www.medicalnewstoday.com/opinions/182663 ; http://www.medicalnewstoday.com/opinions/182620 ; http://www.medicalnewstoday.com/opinions/182611 ; http://www.medicalnewstoday.com/opinions/182577 ; http://www.medicalnewstoday.com/opinions/182265 ; http://www.medicalnewstoday.com/opinions/182534 ; http://www.medicalnewstoday.com/opinions/182518 ; http://www.medicalnewstoday.com/opinions/182513 ; http://www.medicalnewstoday.com/opinions/182447 ; http://www.medicalnewstoday.com/opinions/182422 ; http://www.medicalnewstoday.com/opinions/182373 ; http://www.medicalnewstoday.com/opinions/182300 ; http://www.medicalnewstoday.com/opinions/182280 ; http://www.medicalnewstoday.com/opinions/182265 ; http://www.medicalnewstoday.com/opinions/182238 ; http://www.medicalnewstoday.com/opinions/182187 ; http://www.medicalnewstoday.com/opinions/182123 ; http://www.medicalnewstoday.com/opinions/182081 ; http://www.medicalnewstoday.com/opinions/182051 ; http://www.medicalnewstoday.com/opinions ; http://trendwave.com/Gluten-Free/Opinions-on---Medical-News-Today ; http://trendwave.com/Gluten-Free/Father-Of-Oncology-Discovers-How-Scientists-Invent-New-Drugs- ; https://plus.google.com/107119198688120551734/posts ; https://www.idolbin.com/gprofile/107119198688120551734 ; https://plus.google.com/107119198688120551734/posts/SAbtGRZNduk ; https://www.facebook.com/TheWarOnCancerFoundation/posts/658257930905936 ; https://www.facebook.com/vadim.shapoval.5 ; https://www.facebook.com/pages/International-Agency-for-Research-on-Cancer-IARCWHO/162109297160466 ; https://www.youtube.com/user/1Shapoval ; https://www.youtube.com/watch?v=Tx7W662gd8M ; http://galacticconnection.com/father-oncology-vadim-shapoval-says-cell-needs-iron-overload-becomes-cancerous/ ; http://my.mail.ru/bk/vadim.shapoval/ ; http://russia.ru/id322718 ; http://my.mail.ru/bk/vadim.shapoval/multipost/281A0000F1AF0003.html ; https://answers.yahoo.com/question/index?qid=20111016223132AA727lI ; https://twitter.com/vadimishapoval ; http://www.cancercompass.com/profile/Shapoval ; http://www.ovarian-cancer-facts.com/what-is-cancer.html ; https://disqus.com/by/Shapoval/ ; http://www.merriam-webster.com/dictionary/oncogenesis ; http://www.diapedia.org/associated-disorders/liver-cancer-and-diabetes ; http://zdravv.ru/comments/hyxHUO5MF6o ; http://www.news-medical.net/health/What-Causes-Cancer.aspx ; http://medicalxpress.com/news/2015-01-cooperation-cancer-cells-therapies-ineffective.html ; http://www.medhelp.org/posts/Cancer/High-Iron-Levels/show/1171716 ; http://www.the-scientist.com/?articles.view/articleNo/41449/title/Culturing-Drug-Resistant-Tumors/ ; http://www.bionews.org.uk/page_419747.asp ; http://regator.com/p/267071740/medical_news_today_scientists_discover_new_mechanism_that/ ; http://www.gponline.com/one-two-uk-people-will-develop-cancer-researchers-predict/cancer/article/1332391 ; http://engineeringevil.com/2015/02/05/one-in-2-people-in-the-uk-will-get-cancer/ ; Together We (Mail.Ru, RUSSIA.RU, Google, Facebook, Idolbin, YouTube, Twitter, Diapedia, Yahoo!, Medical News Today, News-Medical.Net, Medical Xpress, MedHelp and Vadim Shapoval) Will Beat CANCER